Star Micronics TSP800RX is a secured prescription printer with "tamper-resistant" features for printing e-prescribing and Centers for Medicare and Medicaid Services (CMS) tamper-resistant prescriptions for the medical professionals in the Healthcare Industry. Theft deterrent features of a locking paper chamber, lock slot for cable harness, and disabled Paper Feed Button provide printing security for the prescription paper roll, printer, and permit only a printed prescription to be emitted from the printer. Secure printing is standardized on the TSP800Rx locking printer by employing accepted industry printer drivers: Windows, MAC (IOS), and Linux (CUPS).